Situated at 104 Pierce Street in La Grange, Missouri, Mark Twain Casino stands across from the Mark Twain Wildlife Refuge on the majestic Mississippi River. Encompassing 18,000 square feet of gaming space, it is equipped with a mix of gaming machines and table games designed to cater to both casual players and serious gamblers. The casino also offers views of the river and surrounding natural beauty, making it a unique destination for visitors.